OM-85 BV produces an effect on innate immunity influencing macrophage and neutrophil activity, and production of pro-inflammatory cytokines (mainly interferon gamma − IFN-γ −, interleukin − IL-2, IL-1, IL-6, IL-8 and tumor necrosis factor alpha − TNF-α), as well as on the immune response regulated by lymphocytes and synthesis of immunoglobulins. This evidence concerns the gene TNF and ocular melanoma.