CXCL8 and type 2 diabetes mellitus: Another study that evaluated the association between urinary cytokine levels and decreased eGFR in patients with T2DM with DN found that increased urinary levels of IL-6, IL-8, TNF-α, and TFG-β were predictors of a faster decline in renal function, indicating the clinical utility of these levels in stratifying the risk of renal disease progression [67].