Patients with T2DM showed a significant decrease in serum IL-4 and TNFR2 levels (p = 0.0165, U = 617, and p = 0.0024, U = 541.5, respectively) and a significant increase in TNFR1 level compared to controls (p = 0.0035; U = 554.5). Here, TNFRSF1A is linked to type 2 diabetes mellitus.