Patients without RA showed a decrease in TNFR2 level compared to the control group (p = 0.0017; H = 12.76, Dunn’s post hoc test), and there was no significant difference in TNF-α (p = 0.9606; H = 0.0803, Dunn’s post hoc test) and IFN-γ levels (p = 0.1986; H = 3.233 Dunn’s post hoc test) between the groups (Fig 1). The gene discussed is TNF; the disease is rheumatoid arthritis.