Thus, our study demonstrates that patients with T2DM with RA show increased stimulation for the recruitment of innate immune cells, through an increase in the serum levels of pro-inflammatory chemokines, stimulated by the increase in adipokines and TNFR1, with consequent decrease in IL-4, favoring the inflammatory process. The gene discussed is TNFRSF1A; the disease is type 2 diabetes mellitus.