Patients with T2DM had a positive and significant correlation between eGFR and IL-4 (p = 0.0346; rS = 0.2428) and a negative and significant correlation between eGFR and TNFR1 (p<0.0001; rS = -0.4559), TNFR2 (p = 0.0096; rS = -0.2956), and leptin (p = 0.0178; rS = -0.2712). The gene discussed is TNFRSF1B; the disease is type 2 diabetes mellitus.