Hypomagnesemia associated with the use of PPI may be partly explained by the renal loss of magnesium due to decreased resorption as well as decreased absorption, as PPI are capable of altering the pH of the gastrointestinal tract, thereby decreasing absorption mediated by TRPM6 and TRPM7 transporters [32]. The gene discussed is TRPM7; the disease is Hypomagnesemia.