SAA4 and rheumatoid arthritis: ORM2 was founded to be associated with microglial interaction (Jo et al. 2017), SAA4 was identified as a rheumatoid arthritis-screening biomarker (Seok et al. 2017), and MAP2K6 was reported to be involved in the pathogenesis of colorectal adenocarcinoma (Rasmussen et al. 2016).