Indeed, Prx-/- mice display a progressive peripheral neuropathy including axon/myelin-units with abnormal myelin thickness, demyelination, tomaculae, onion bulbs, reduced nerve conduction velocity (Gillespie et al., 2000), reduced abundance and mislocalization of the periaxin-associated DRP2 (Sherman et al., 2001) and reduced internode length (Court et al., 2004). This evidence concerns the gene PRX and peripheral neuropathy.