Spautin‐1, as a potential USP10/13 antagonist, was reported to play an anti‐tumour effect in various cancers, such as chronic myeloid leukaemia, ovarian cancer and lung cancer.13 In this study, we investigated the role of spautin‐1 in malignant melanoma. The gene discussed is USP10; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.