Spautin‐1, a USP10/USP13 inhibitor, was also reported to be an autophagy inhibitor by enhancing the degradation of beclin‐1, a protein required for the initiation of autophagy.12 It was reported that loss of beclin‐1 could lead to DNA damage.25 Previous study showed that spautin‐1 inhibits cell growth and angiogenesis through inactivating the PI3K/AKT pathway in chronic myeloid leukaemia.26 In particular, it can suppress the growth of ovarian cancer and lung cancer by regulating MCL1 stability.24 However, its role in malignant melanoma has not been appreciated thus far. This evidence concerns the gene USP10 and melanoma.