In particular, the advent of some new inhibitors revealed suppressive effect in melanoma.8, 9 Ubiquitin‐specific peptidase10 (USP10) and ubiquitin‐specific peptidase 13 (USP13) both belong to USP family, the largest subfamily of DUB.10 USP10 and USP13 are involved in a number of biological processes and impact the development of various tumours by stabilizing several proteins. Here, USP13 is linked to melanoma.