ADM2 and hypotensive disorder: Adm2, gene encoding for Adrenomedullin 2, a signalling peptide known to cause vasodilation, hypotension, being involved in regulation of endothelial cell permeability and induced by hypoxia.28, 29, 30 These functions suggest that Adrenomedullin 2 could lead to pulmonary vasodilation, causing pulmonary hypotension that results in decreased stroke volume.