The major ≥ grade 3 adverse events were anemia (n = 3), cutaneous toxicity (n = 3), stomatitis (n = 2), leukopenia (n = 2), neutropenia (n = 2), and aspartate aminotransferase/alanine aminotransferase elevation (n = 2). This evidence concerns the gene GPT and Decreased total leukocyte count.