We asked if Kcna1-dCas9A was able to rescue transcriptomic changes in the temporal lobe epilepsy model by performing RNAseq analysis on hippocampi from sham control animals injected with Ctrl-dCas9A and epileptic animals injected either with Ctrl-dCas9A or with Kcna1-dCas9A. Here, KCNA1 is linked to temporal lobe epilepsy.