Moreover, circulating adiponectin level is associated with tumor necrosis factor-α (TNF-α) level [19,23,25], C-reactive protein (CRP) level [20,22], interleukin-8 (IL-8) level [25] and interleukin-6 (IL-6) level [25] in COPD patients. This evidence concerns the gene ADIPOQ and chronic obstructive pulmonary disease.