MIR155HG and chronic obstructive pulmonary disease: Additionally, a negatively between MIR155HG and miR-218-5p in the tissues of smokers with COPD was observed (Figure 3E), and MIR155HG overexpression inhibited miR-218-5p expression, while MIR155HG deletion promoted miR-218-5p expression in HPMECs (Figure 3F).