DNM2 and autosomal dominant centronuclear myopathy: Focusing on components of the neuromuscular circuit which are affected in CMT and autosomal-dominant centronuclear myopathy [CNM, a second disease associated with a distinct set of DNM2 mutations (22)], ablation of DNM2 specifically in mouse skeletal muscle resulted in muscle fibre atrophy and loss, altered neuromuscular junctions, degenerating nerve fibres, accumulation of lipid droplets and mitochondrial abnormalities (23).