Since the transcriptional effects observed in the knock‐down cell lines by GO term analysis pointed towards pathways frequently found deregulated in SCC tumours (Rocco et al, 2006; Koster et al, 2007), which was also observed by the strong effects on KRT5, KRT14 and KRT19 expression (Fig 4H, J and L), we next wanted to know whether other SCC markers are also regulated by the USP28/∆Np63 axis. The gene discussed is USP28; the disease is neoplasm.