∆Np63 is essential for the survival of skin and pancreatic SCC cells, since established murine skin SCCs are exquisitely dependent on ∆Np63; acute deletion of TP63 in advanced, invasive SCC induced rapid and dramatic apoptosis and tumour regression (Rocco et al, 2006; Galli et al, 2010; Ramsey et al, 2013; Su et al, 2013; Somerville et al, 2018). Here, TP63 is linked to neoplasm.