Both SCC cells and tumours depend on ∆Np63 for maintaining proliferation and cell identity by maintaining the expression of lineage markers of keratinization, such as keratins 5 and 14, which are not found in ADC (McDade et al, 2011; Lau et al, 2013; Ramsey et al, 2013). The gene discussed is KRT5; the disease is neoplasm.