Loss of USP28 counteracts the loss of Fbxw7 in a murine colon tumour model (Diefenbacher et al, 2015; Cremona et al, 2016), and acute deletion of USP28 in established tumours increases survival in the APCmin∆/+ colorectal tumour model (Diefenbacher et al, 2014), while not affecting tissue homeostasis in non‐transformed cells (Schulein‐Volk et al, 2014). Here, USP28 is linked to neoplasm.