NR3C2 and Hypertension: Sodium and volume retention caused by MR activation contributes to renal damage (including vascular and glomerular sclerosis, tubular damage and inflammation) in rodent experimental models of hypertension (Blasi et al., 2003; Nishiyama et al., 2004; Sun et al., 2006), and protection conferred by MRA blockade can occur partly due to decreases in systolic blood pressure (Du et al., 2009; Martín‐Fernández et al., 2016; Zhou et al., 2011).