NR3C2 and endothelial dysfunction: MR activation in vascular endothelial cells and VSMCs results in endothelial dysfunction, increased oxidative stress (where the production of potentially damaging reactive oxygen species [ROS] exceeds endogenous antioxidant capacity) and ultimately vascular injury and remodelling, leading to reduced arterial compliance and vasoconstriction (Duprez, 2007; Gros et al., 2007; Jaffe & Mendelsohn, 2005; Nguyen Dahn Cat et al., 2010; Struthers, 2004).