NR3C2 and endothelial dysfunction: Data suggest that oxidative stress is a central mechanism by which aldosterone\MR activation causes renal damage (Nishiyama & Abe, 2006; Nishiyama et al., 2004), particularly vascular injury\endothelial dysfunction, renal cell apoptosis, inflammation and fibrosis (Leopold et al., 2007; Sanz‐Rosa et al., 2005; Sun et al., 2002; Sun, Zhang, Zhang, & Ramires, 2000; Terada et al., 2005).