NR3C2 and Hypertension: Lower plasma potassium tends to be a risk factor for feline hypertension in epidemiological studies, providing support for MR activation (Jepson et al., 2009; Sansom, Rogers, & Wood, 2004; Syme, Barber, Markwell, & Elliott, 2002), although blood pressure is not directly associated with plasma or urinary aldosterone concentrations (Syme, Barber, et al., 2002; Syme et al., 2007; Williams et al., 2013).