NR3C2 and chronic kidney disease: In fact, in humans and laboratory species, MR blockade has been shown to be beneficial in the absence of elevated plasma aldosterone levels (Du et al., 2009; Nagase, Matsui, Shibata, Gotoda, & Fujita, 2007; Nagase et al., 2006; Pitt, Remme, Zannad, & Neaton, 2003; Pitt et al., 1999) and renal MR expression is not correlated with serum aldosterone levels in people with CKD (Quinkler et al., 2005).