Increased plasma aldosterone concentration is not seemingly driven by plasma renin activity, as cats with concurrent CKD and hypertension have variable or decreased renin compared with controls, resulting in increased aldosterone‐to‐renin ratios (Jensen et al., 1997; Jepson et al., 2014; Syme, Markwell, et al., 2002). This evidence concerns the gene REN and hypertensive disorder.