Hypomagnesaemia is associated with systemic hypertension in cats with CKD (van den Broek, Chang, Elliott, & Jepson, 2018a) and MR activation may provide the link between these factors, as urinary magnesium excretion is stimulated by aldosterone (Barr et al., 1995) and aldosterone secretion is inhibited by increased circulating magnesium levels (Atarashi, Matsuoka, Takagi, & Sugimoto, 1989). This evidence concerns the gene NR3C2 and chronic kidney disease.