An enhanced MR effector mechanism is closely related to proteinuria, a strong risk factor for CKD progression in people (Heerspink, Kröpelin, Hoekman, & de Zeeuw, 2015) and prognosis in cats (Chakrabarti et al., 2012; King et al., 2007; Kuwahara, Ohba, & Kitoh, 2006; Syme et al., 2006). The gene discussed is NR3C2; the disease is chronic kidney disease.