INS and type 2 diabetes mellitus: In line with that, T2D patients are routinely prescribed with 1–3 hypolipidemic agents (high-intensity statin, ezetimibe, fibrates, anti-PCSK9 antibody [40]), aspirin, and 1–3 hypotensive drugs (beta-blocker, thiazide, Ca-channel blocker, ACEi, angiotensin receptor blocker (ARB)), in addition to 1–6 hypoglycemic agents (metformin, sulphonylurea, DPP4i, SGLT2i, GLP1 analog, acarbose, insulin(s)) [1].