INS and type 2 diabetes mellitus: Moreover, the mitochondrial dysfunction narrative still leaves unresolved the insulin sensitizers’ riddle, whereby anti-diabetic agents that promote sensitization to insulin e.g., biguanides / metformin, thiazolidinedioones / pioglitazone, high-dose aspirin, berberine and others, are all reported to act as mitochondrial complex I inhibitors [84], implying that ‘mitochondrial dysfunction’ is more of a solution rather than a problem in the T2D context [85].