In line with that, T2D may be alleviated by suppressing mTORC1 hyper activation. Specifically, mTORC1 hyper activation may be driven by chronic dietary carbohydrate excess of high glycemic index, resulting in concomitant activation of the glucose-induced RagA/B.GTP and the insulin-induced Rheb.GTP drivers of mTORC1. Here, RHEB is linked to type 2 diabetes mellitus.