For example, mice with a transgenic overexpression of the insulin-sensitizing adipokine adiponectin or the mitochondrial protein mitoNEET—both on the background of leptin-deficient ob/ob mice—resemble the human MHO phenotype with preserved insulin sensitivity and low liver and muscle fat despite extreme obesity (66, 67). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.