Cancer cells frequently acquire SEs to promote oncogene expression, which mediates the dysregulation of signaling pathways.21,33,35,53 Colorectal cancer (CRC) is driven by various oncogenic pathways,14 and CRC-associated SEs are enriched in transcription factor 4 (TCF4) binding sites.36 CRC-associated SEs are found in CRC cells but not in normal colon cells, indicating that these SEs are specific to CRC tumorigenesis. Here, TCF4 is linked to colorectal cancer.