BRD4 and cancer: Such an SE-driven transcriptional program is mainly dependent on BRD4; it is important to maintain oncogenic identity and pluripotency.76,81 iBET, which is similar to JQ1, has also been applied for cancer treatment.82 In addition to BET inhibitors, targeting CDKs to regulate RNAPII initiation and elongation shows great potential83 (Table 2).