In lung adenocarcinoma, the focal amplification of ~450 kb downstream of the MYC locus leads to SE formation, and drives high expression of the oncogene, in which NFE2L2 and CEBPB are necessary to maintain SE activity.74 A chromosomal translocation in ACC repositions an unrelated SE in proximity to the MYB oncogene, resulting in high MYB expression75 (Table 1). The gene discussed is MYB; the disease is lung adenocarcinoma.