ORMDL3 and inflammatory bowel disease: We hypothesized that the TFs IKZF1 and IKZF3 may regulate the expression of FUT8. We further observed notable pleiotropy between variants in the IKZF3-ORMDL3-GSDMB-ZPBP2 locus with inflammatory conditions including inflammatory bowel disease (IBD), ulcerative colitis (UC), and rheumatoid arthritis (RA) (Fig. 2).