PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Interestingly, after adjustment for SHBG levels, HIV infection was no longer significantly associated with lower NAFLD odds (OR, 0.61; 95% CI, 0.34–1.08), whereas associations of VAT, HOMA-IR, black race, and PNPLA3 non-CC genotype with NAFLD were unchanged (Table 2).