To measure the activation of tumor-induced osteoclastic bone resorption, TGFβ, an ECM-enriched growth factor, was measured.16 The expression and activity of Src is known to correlate with advanced malignancy and poor prognosis in a variety of cancers.17,18 Osteopontin (OPN) is known to play a role in cell adhesion and migration and tumorigenesis.19 Mass spectrometry-based protein analysis predicted the involvement of OPN in the mechanosensitive migratory behaviors of tumor cells. Here, SPP1 is linked to neoplasm.