TGFB1 and intervertebral disk degenerative disorder: Despite studies investigating the antifibrotic potential of TGFβ/Smad inhibition, we believe that the early induction of TGFβ-mediated fibrosis by fibroblast injection intervention in the acute and subacute stages of IDD will benefit patients by stabilizing and maintaining disc height to minimize the loss of biomechanical functions of the intervertebral disc.