ABHD8 and ovarian carcinoma: This prediction is in accordance to what has been functionally validated for other candidate rSNP rs1154085520 in ABHD8. Previously, rs4808616 had been also functionally studied for mechanisms underlying pleiotropic risk to breast and ovarian cancer.47 The authors found evidence of allelic expression and identified multiple risk alleles, which they associated with increased ABHD8 promoter activity.