INS and obesity due to melanocortin 4 receptor deficiency: Therefore, adipose tissue may be considered an immunological organ since these immune cells can secrete pro‐inflammatory and anti‐inflammatory cytokines affecting adipocyte biology, metabolism, and systemic inflammation, and being a key factor in insulin resistance development and obesity‐related pathologies.2, 5 However, some patients with obesity show normal glucose homeostasis,6 and previously unrecognized molecules could be involved in this situation.