Nicotinate and nicotinamide metabolism pathway (P-value = 0.000225), DNA damage recognition in global genome nucleotide excision repair (GG-NER) (P-value= 0.00156), and degradation of AXIN (P-value= 0.00156) were the top three impaired pathways in LN patients. This evidence concerns the gene AXIN1 and lobular neoplasia.