He et al. reported salidroside mitigated sepsis-induced myocarditis by downregulating PI3K/Akt/GSK-3β signaling (46); Song et al. found curcumin protected mice from coxsackievirus B3-induced myocarditis by inhibiting the PI3K/Akt/NF-κB pathway (13); Other reported PI3K inhibitor LY294002 promoted apoptosis in coxsackievirus 3 infected HeLa cells and reduced cardiac necrosis, inflammatory infiltrates, and CD3(+) T cells in EAM mice via down-regulation of p-Akt (14,15). This evidence concerns the gene NFKB1 and myocarditis.