Validation of circRNAs and their corresponding miRNAs and mRNAs by bioinformatical analysis through screening demonstrated that the resistance of NPC CNE-2 cells to radiation was regulated by the change in the “hsa_circRNA_102115”-“hsa-miR-335-3p” -“IGF1R/MAPK1” network. Here, MAPK1 is linked to nasopharyngeal carcinoma.