Furthermore, data of immunohistochemical analysis demonstrated that baicalin treatment in vivo enhanced the expression of E-cadherin and reduced the expressions of Ki67, Vimentin, N-cadherin, CD133 and CD44 by comparing with negative control in HCT116 orthotopic transplanted colorectal tumors (Fig. 8E). The gene discussed is CDH2; the disease is colorectal neoplasm.