In contrast, some researchers 29, 30 have found that lung adenocarcinomas harboring some EGFR mutations exhibited increased cancer cell invasive ability and promoted malignant pleural effusion formation, and Zhu et al 31 have reported that Mt has a higher TP53 mutation rate and a higher Ki67 expression compared with Wt, suggesting that Mt is more aggressive. Here, TP53 is linked to lung adenocarcinoma.