Similarly, YWHAZ overexpression was significantly associated with reduced disease-free survival/overall survival and earlier time to disease recurrence, and death in breast cancer by combining with elevated levels of Akt, FOXM1, ErbB2, LOC441453 and LAPTM4B 31, 32, 35, 36, 39, 78-80. The gene discussed is LAPTM4B; the disease is breast cancer.