In HCC, αB-Crystallin-YWHAZ complexes were observed to promote EMT through elevated ERK1/2 phosphorylation, which impaired the effect of sorafenib, while JNK and p38/MAPK phosphorylation were verified to increase chemosensitivity of HCC cells to CDDP when YWHAZ was silenced 11, 14. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.