Tyrosine 3 monooxygenase/tryptophan 5-monooxygenase activation protein zeta (also named 14-3-3ζ or YWHAZ), belonging to the 14-3-3 protein family, is a central hub protein involved in many signal transduction pathways and plays a key role in tumor progression 1, 2, 5-8. Here, YWHAZ is linked to neoplasm.