Silencing of YWHAZ accelerated miR-375-induced apoptosis by caspase-3/ caspase-7 activation and promoted autophagy by PI3K/AKT/mTOR signaling pathway 22, 23, as well as inhibiting cell proliferation, migration/invasion and EMT in GC 20, 21. The gene discussed is YWHAZ; the disease is gastric cancer.