AKT1 and familial pancreatic carcinoma: In previous research, Gumireddy K et al. found that GABRA3 can promote cell invasion, migration and metastasis through AKT pathway in breast cancer 37, Recent studies have shown that miR-92b-3p targets and reduces GABRA3 expression and thus inhibits pancreatic cancer cell invasion and migration 38, GABRA3 also plays an important role in the occurrence and development of liver cancer and lung cancer 39, 40.