Because SNAIL1 is one of the β-catenin regulated genes, and Wnt/β-catenin signaling is associated with cell invasion and EMT 25, 46, our data thus suggested that the inhibitory effects of CDH13 on PC invasion and EMT may be mediated via the Wnt/β-catenin signaling pathway. Here, CDH13 is linked to pachyonychia congenita.