LMP1, as an EBV-encoded viral antigen, is a kind of oncogenic gene and participates in the activation of signaling pathways such as NF-κB, JNK-p38/SAPK, Ras-MAPK, PI3k-Akt and JAK-STAT, which can promote the occurrence of EMT and make nasopharyngeal carcinoma has a higher invasion and metastasis ability, which is considered to be an important factor in the development of nasopharyngeal carcinoma 42. Here, NFKB1 is linked to nasopharyngeal carcinoma.