To determine the exact role of ITGB4 and ITGB7 in development of liver cancer, we used Si-ITGB4-4204 and Si-ITGB4-5690 to knockdown ITGB4, and Si-ITGB7-5402 and Si-ITGB7-5404 to knockdown ITGB7 gene in Bel-7402. This evidence concerns the gene ITGB7 and liver cancer.