Other studies have also suggested some potential combinations of markers, such as the combination of GP73, GPC3 and CD34 can improve the specificity of HCC diagnosis to 96.6% 81; the combination of GPC3 and CK19 can be used for differential diagnosis of liver cancer and intrahepatic cholangiocarcinoma (accuracy was 73.5%) 82; GPC3 combined with Arginase-1 and HepPar-1 can further improve the diagnostic accuracy 83. This evidence concerns the gene KRT19 and intrahepatic cholangiocarcinoma.