KRAS and familial pancreatic carcinoma: Aikawa, T et al. found that GPC1 is associated with pancreatic cancer growth, migration and angiogenesis 19; in addition, Whipple, CA et al. revealed that in KRAS mutation-induced pancreatic cancer, GPC1 is the key molecule for tumor growth and angiogenesis 20; exosomes containing GPC1 in peripheral blood can be used as biomarkers for the diagnosis of pancreatic cancer.