The ceRNA network, especially the subnetwork LncRNA (KCNQ1OT1)-miRNA (has-miR-29c-3p)–mRNA (JARID2, CDK8, DNMT3A, TET1) represents a promising therapeutic target for treating the STS sub-cluster of patients with a poor prognosis. Here, KCNQ1OT1 is linked to telomere syndrome.