It was reported to promote the invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through the PTEN/AKT signaling pathways (Lei et al., 2016) and is essential for the maintenance of tumor-initiating cells in bladder cancer (Zhu et al., 2017). This evidence concerns the gene AKT1 and urinary bladder carcinoma.