For the Metabolic Syndrome in Men dataset, mDAG also identifies the expected paths of important GWAS loci for adiponectin suggested by previous publications (Civelek et al., 2017; Martin et al., 2017), even in the presence of multiple presumably irrelevant genes in the 1D neighborhood of the loci under study in the model, indicating that mDAG can bridge the functional gap of synonymous GWAS signals and provide the mechanistic hypotheses underlying GWAS variants. This evidence concerns the gene ADIPOQ and metabolic syndrome.