For example, glycolysis-associated enzymes such as phosphoenolpyruvate carboxykinase 1, 2 (PCK1, 2) and enzyme fructose-1,6-bisphosphatase 1 (FBP1), were downregulated in in two tumors, which resulted in glucose intake and kept tumor cells survive [10, 11]. The gene discussed is PCK1; the disease is neoplasm.