CEBPA and acute myeloid leukemia: Bi-allelic CEBPA mutations confer a favorable prognosis to patients with AML with a normal karyotype [1, 8] and typically combine an N-terminal frameshift mutation within the first 357 bp of the coding sequence on one allele with a C-terminal in-frame insertion or deletion between c.834-1074 that disrupts the DNA-binding basic zipper (bZIP) domain on the other allele [28].