To evaluate whether the therapeutic efficacy of anti-neu mAb therapy would be stronger when the tumour is more immunogenic, we used a transplantable tumour model, the oncogenic rat-neu (NeuT) expressing tumour cell line (TUBO) established from a spontaneously developed mammary gland tumour of a female BALB/c-NeuT mouse12. Here, ERBB2 is linked to neoplasm.