Consistent with the data showing a lack of an effect on peroxisome biogenesis factor levels, infection with HIV-1 harboring mutated Vpu did not significantly increase the expression of miR-500a-5p, miR-34c-3p, miR-93-3p, or miR-381-3p in HeLa-CD4/CXCR4/CCR5 cells, macrophages, or T cells (Fig. S2). Here, CCR5 is linked to infection.