Here, using a mouse model of RRV-induced myositis, we showed that muscle tissue inflammation follows a bimodal inflammatory process driven by CD11bhi Ly6Chi inflammatory monocytes (IM), culminating in a recovery phase associated with the establishment of a CX3CR1+ CD11bhi Ly6Clo macrophage (MP) population. Here, CX3CR1 is linked to myositis disease.