IFNG and myositis disease: Of note, IFN-γ-induced Cxcl10 gene expression was downregulated in IM isolated from the muscle of IMP-treated mice, and together with the reduced IFN-γ protein levels we observed in the muscle, our data point toward an important role for IFN-γ and CXC chemokine ligand 10 (CXCL10)-CXC chemokine receptor 3 (CXCR3) pathways in RRV-induced myositis.