Specifically, we tested for an association between the square-root-transformed age at the first P. aeruginosa infection and 17,139 SNPs in Chr 1 Mb 97.0 to 105.0 of hg19 in 712 individuals of European descent with severe CFTR genotypes known to be associated with pancreatic insufficiency (Table S2A). This evidence concerns the gene CFTR and exocrine pancreatic insufficiency.