HLA-B*08:01 was the locus with the strongest association: in the largest series with complete genotyping, it was carried by 69% of non-paraneoplastic LEMS vs. 23% of the control group (p < 0.001), and 12% of paraneoplastic LEMS (p < 0.001) [35, 37]. This evidence concerns the gene HLA-B and Lambert-Eaton myasthenic syndrome.