The extended, highly conserved, haplotype 8.1 (A*01:01-B*08:01-DQB1*02:01-DRB1*03:01) or its components have been found to be more frequent in non-paraneoplastic LEMS of Caucasian-origin than in healthy controls or paraneoplastic LEMS [33–37]. The gene discussed is HLA-DRB1; the disease is Lambert-Eaton myasthenic syndrome.