More recently, it has been shown that class II HLA DQB1*02 and DRB1*03 are more frequent among anti-Hu PNS patients of Caucasian origin (62 and 47% of 53 patients studied) than in healthy, blood donors, controls (37% carried DQB1*02, p < 0.005; and 25% DRB1*03, p < 0.01); carrier frequencies were lower in neurologically asymptomatic SCLC patients lacking anti-Hu Ab (29% carried DQB1*02 and 21% DRB1*03), but did not reach significance, likely due to small sample size (n = 26) [23]. This evidence concerns the gene HLA-DRB1 and paraneoplastic neurologic syndrome.