We know that during HIV-1 infection, HIV-IN binds to the IBD and uses DFS70/LEDGF to tether the viral genome to active chromatin as a mechanism to ensure efficient viral integration and replication, and that during virus assembly the integrase keeps this protein associated with the viral particle, most likely to provide an integration advantage to newly released virions [143]. The gene discussed is PSIP1; the disease is HIV-1 infection.