PSIP1 and cancer: As mentioned above, our research on the role of DFS70/LEDGF in cancer was triggered by the observation that PCa patients who came to Loma Linda University Medical Center for proton therapy exhibited a relatively elevated frequency of antibodies presenting the DFS IIF pattern in HEp-2 cells (14%, 29 out of 207 patients) compared to matched controls (4.2%) and blood bank donors (2.3%) [79].