ATM and neoplasm: ClinVar Miner recapitulates the great diversity of variants in quantity and quality, for more than 30,000 genes, highlighting three important characteristics: i) the genes with the highest number of submitted variants include the most relevant tumor risk genes, such as BRCA1 and BRCA2, APC, mismatch repair genes, and ATM (Table 5), ii) many submitted variants have conflicting interpretation and/or redundant significance, and iii) a large amount of total variants is represented by VUS (Table 6).