Following our observation on MACs reduce neuroinflammation induced by the HF-FD diet, we further evaluated PTP1B (a mediator cross-linking inflammation and abnormal synaptogenesis) and synaptic signaling pathway IRS-pAKT-pGSK3β-pTau, which plays an important role in synaptogenesis [44]. Here, IARS1 is linked to hydrops fetalis.