Aberrations in the ubiquitin system also have been reported to be associated with various diseases, including cancer, for example, with elevated expression of Cathepsin D and Ubiquitin C-terminal hydrolase-L1 in tumor cells, the incidence of lymph node metastasis in CRC also has increased [28]. This evidence concerns the gene UCHL1 and metastatic malignant neoplasm in the lymph nodes.