Xue et al. [37] reported that the activity of CDK1 is highly elevated in CRC tissues compared to noncancerous tissues, and it predicts distant metastasis risk in CRC; CDK1 can promote the progression of CRC through phosphorylation of JAK1 to activate the JAK/STAT3 signaling pathway. The gene discussed is JAK1; the disease is colorectal carcinoma.