Baseline CD4 count (AHR = 0.99, 95% CI [0.98–0.99]), Severe acute malnutrition (AHR = 15.92, 95% CI [5.34–47.50]), and exposure to tuberculosis treatment (AHR = 2.93, 95% CI [1.39–6.17]) were the independent predictors for the development of OIs. The gene discussed is CD4; the disease is tuberculosis.