Multiple non‐DNA damaging stimuli, such as heat, chloroquine, and hypoxia, could increase the activity of ATM/ATR.32 The results also indicated that bortezomib treatment leads to the activation of ATM/ATR, inducing the glioma cells to undergo apoptosis, and inhibition of PLK4 expression enhances this effect. The gene discussed is ATM; the disease is central nervous system cancer.