Previous studies have shown that bortezomib disrupts multiple downstream signalling pathways, such as the NF‐κB signalling pathway and ubiquitin‐proteasome pathway, and has an important role in the regulation of cell cycle, mitosis, cell viability, proliferation and apoptosis in glioblastoma cells.6, 7, 8 It also blocks autophagy flux mediated by the 26S proteasome, thereby inhibiting the elimination of damaged organelles,9 and inhibits the proliferation of glioblastoma. Here, NFKB1 is linked to glioblastoma.