Klaus et al. have also proved that adiponectin promotes higher-yield secretion of chemical mediators (i.e., MCP-1, IL-6, IL-8 and MMP-3) from RA synovial fibroblasts compared to those in osteoarthritis, and that it induces lymphocytes to synthesize TNFα, IL-6 and IL-8 [39]. This evidence concerns the gene MMP3 and osteoarthritis.